Naoki Koyama Selected Research

ferulic acid (sodium ferulate)

1/2017	Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.
1/2013	Ferulic acid is a nutraceutical β-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice.

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Naoki Koyama Research Topics

Disease

8	Amyloid Plaque 01/2023 - 02/2010
8	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 02/2010
6	Amyloidosis 11/2020 - 02/2012
4	Neoplasms (Cancer) 03/2022 - 04/2008
4	Neuroinflammatory Diseases 11/2020 - 02/2012
3	Cognitive Dysfunction 01/2023 - 02/2012
3	Carcinogenesis 03/2022 - 04/2008
2	Colitis 03/2022 - 10/2015
1	Adenocarcinoma 03/2022
1	Malaria 01/2016
1	Methemoglobinemia 10/2014
1	Carcinoma (Carcinomatosis) 03/2010
1	Urinary Bladder Neoplasms (Bladder Cancer) 03/2010
1	Dementia (Dementias) 02/2010
1	Gliosis 02/2010
1	Inflammation (Inflammations) 04/2008
1	Zellweger Syndrome (Zellweger's Syndrome) 06/2004

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 01/2023 - 06/2004
8	Amyloid (Amyloid Fibrils)IBA 01/2023 - 02/2010
4	Peptides (Polypeptides)IBA 10/2014 - 02/2010
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 11/2020 - 02/2012
3	Presenilin-1IBA 01/2019 - 02/2012
3	EnzymesIBA 01/2013 - 02/2010
2	Dextran SulfateIBA 03/2022 - 10/2015
2	CateninsIBA 03/2022 - 10/2015
2	Benzo(a)pyreneIBA 03/2022 - 10/2015
2	ferulic acid (sodium ferulate)IBA 01/2017 - 01/2013
1	Apolipoproteins E (ApoE)IBA 01/2023
1	ApolipoproteinsIBA 01/2023
1	o-AminoazotolueneIBA 03/2022
1	anthraceneIBA 03/2022
1	AzoxymethaneIBA 03/2022
1	CarcinogensIBA 03/2022
1	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 03/2022
1	PhytochemicalsIBA 11/2020
1	Gallic AcidIBA 11/2020
1	PresenilinsIBA 01/2017
1	octyl gallateIBA 01/2017
1	hemozoinIBA 01/2016
1	InterferonsIBA 10/2015
1	Membrane Proteins (Integral Membrane Proteins)IBA 10/2015
1	Methylene Blue (Methylthioninium Chloride)FDA Link 10/2014
1	Tannic Acid FDA Link 02/2012
1	FlavonoidsIBA 02/2012
1	Tyrosine Kinase InhibitorsIBA 03/2010
1	Urea (Carbamide)FDA LinkGeneric 03/2010
1	PD 173074IBA 03/2010
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 03/2010
1	Amyloid beta-PeptidesIBA 02/2010
1	CytokinesIBA 02/2010
1	deoxyinosineIBA 04/2008
1	DNA AdductsIBA 04/2008
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2008
1	2'-deoxyxanthosineIBA 04/2008
1	A-factor (Streptomyces)IBA 04/2008

Therapy/Procedure

3	Therapeutics 01/2023 - 01/2017
2	Aftercare (After-Treatment) 03/2022 - 10/2015